Research

ZYMUTEST™ Factor IX Measurement of FIX in human plasma, by Elisa.

COMPLETE SOLUTION Product Name RS Ref. Presentation ZYMUTEST™

Factor IX RUO RK032A 96 tests

VON WILLEBRAND DISEASE (VWD) (3)

Willebrand s disease is the most common bleeding disorder. It concerns a group of various types of von Willebrand disease. vWF functional or quantitative deficiency allows characterizing von Willebrand disease, which can be classed into 3 types: - Type 1: vWD is characterized by a partial quantitative deficit of vWF (most frequently). - Type 2: vWD is characterized by an abnormal vWF adhesion activity. It is divided into 4

subtypes: 2A, 2B, 2M and 2N, depending on the multimers functional abnormality. - Type 3: vWD is characterized by a severe quantitative vWF deficiency.

vWF deficiencies can be associated with various other pathologies, thus constituting an acquired von Willebrand disease. When vascular endothelium is affected, the vWF concentration can be increased in relation to inflammatory processes.

LIAPHEN™ vWF:Ag Measurement of von Willebrand Factor Antigen (vWF: Ag), in human citrated plasma, with a latex turbidimetric assay.

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

LIAPHEN™ vWF:Ag Liquid and Ready to use

CE-IVD 120206 R1: 4 x 5 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 R2: 4 x 6 mL

ZYMUTEST™ vWF Measurement of von Willebrand Factor (vWF) in human plasma, by Elisa.

COMPLETE SOLUTION Product Name RS Ref. Presentation

ZYMUTEST™ vWF CE-IVD RK030A 96 tests

ZYMUTEST™ vWF:CBA Measurement of human von Willebrand Factor (vWF) Collagen Binding Activity (CBA) in human activated plasma.

COMPLETE SOLUTION Product Name RS Ref. Presentation ZYMUTEST™

vWF:CBA CE-IVD RK038A 96 tests

Research

vWF Deficient Plasma For any study or research protocol where a source of human vWF deficient plasma is required.

COMPLETE SOLUTION Product Name RS Ref. Presentation vWF Deficient

Plasma RUO DP150K 6 x 1 mL

OTHER BLEEDING DISORDERS

FACTOR XII (FXII) (1,3) Most affected individuals with FXII deficiency are asymptomatic and have rarely a mild tendency to bleed. However, they can show an impaired fibrinolysis, which can expose them to thrombosis.

Since bleeding time is usually normal, diagnosis is characterized by a prolonged activated partial thromboplastin time (aPTT) test. A specific FXII assay helps to confirm the diagnosis.

Factor XII Deficient Plasma Used in combination with CEPHEN™ (ref. CK511K CK512K CK515K CK515L) to measure FXII clotting activity in human citrated plasma.

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

Factor XII Deficient Plasma

CE-IVD DP080A 1 x 1 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 DP080K 6 x 1 mL

FACTOR XI (FXI) (2) FXI deficiency is a very rare disease. It is an inherited genetic disorder, affecting both women and men. Bleeding has a variable expression in the affected kindreds, it is not always dependent on the residual FXI concentration.

Factor XI Deficient Plasma Used in combination with CEPHEN™ (ref. CK511K CK512K CK515K CK515L) to measure FXI clotting activity in human citrated plasma.

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

Factor XI Deficient Plasma

CE-IVD DP070A 1 x 1 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301DP070K 6 x 1 mL

(3) www.hemophilia.org (1) cf Dedicated intructions for use - (2) www.afh.asso.fr - (3) www.hemophilia.org

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