Anticoagulants are widely used to prevent and treat thromboembolic disorders. The major groups are Anti-aggregants, Vitamin K antagonists, Polysaccharide anticoagulants (like heparins) and Direct Oral Anticoagulants (DOACs), targeted to thrombin or Factor Xa. The major risks are bleeding (excess of drug), or recurrent thrombosis (insufficient dosage). Direct Oral Anticoagulants (DOACs) are becoming more and more used. In some situations, such as overdosage, bleeding, urgent surgery or non-compliance with therapeutic protocol, measurement of their anticoagulant activity in plasma is essential. Dedicated assays, calibrated with a like to like drug in plasma, are proposed for these applications. Patient follow-up is based on the evaluation of the response to anticoagulant therapy and the early detection of relapses.
Assay portfolio for anticoagulants
RS DRUG
REAGENT
HIT Isotype
Heparin induced Thrombocytopenia
Anti-Xa Anti-IIa
CE -IV
D
BIOPHEN™ Heparin LRT 221011 - 221013- 221015 BIOPHEN™ DiXaI 221030 HEMOCLOT™ Thrombin Inhibitors CK002K - CK002L BIOPHEN™ DTI 220202 ZYMUTEST™ HIA IgM RK040B - on-demand ZYMUTEST™ HIA IgA RK040C - on-demand ZYMUTEST™ HIA IgG, IgA, IgM RK040E - on-demand
RU O
BIOPHEN™ Heparin (AT+) 221007 * * *
BIOPHEN™ Anti-Xa (2 stages Heparin Assay) 221005
* *
BIOPHEN™ Anti-IIa (2 stages Heparin Assay) 220005
*
CE -IV
D 5 10
(k )
BIOPHEN™ Heparin 221003 - 221006 ZYMUTEST™ HIA IgG RK040A ZYMUTEST™ HIA IgGAM RK040D ZYMUTEST™ HIA Mono Strip, IgG RK041A ZYMUTEST™ HIA Mono Strip, IgGAM RK041D
*RUO kit
BIOPHEN™ UFH Calibrator222301
BIOPHEN™ Rivaroxaban Calibrator
226001 - 222701
BIOPHEN™ Apixaban Calibrator
226101 - 226201
BIOPHEN™ Edoxaban Calibrator
226401 - 226501
BIOPHEN™ Orgaran Calibrator222201
BIOPHEN™ Dabigatran Calibrator
222901 - 222801
BIOPHEN™ Bivalirudin Calibrator226701
Argatroban Plasma CalibratorSC030K
BIOPHEN™ Heparin Calibrator222001
BIOPHEN™ Arixtra Calibrator222501
UFH
Rivadoxaban Apixaban
Edoxaban
Danaparoïd
Dabigatran
Bivalirudin
Argatroban
UFH - LMWH
Fondaparinux
CALIBRATORS
GL OB
AL &
RO UT
IN E
TE ST
S FI
BR IN
OL YS
IS TH
RO M
BO PH
IL IA
RE SE
AR CH
PR IM
AR Y
HE M
OS TA
SI S
CA LI
BR AT
OR S
& CO
NT RO
LS IN
DE X
M ON
IT OR
IN G
AN TI
CO AG
UL AN
T AU
XI LI
AR Y
RE AG
EN TS
BL EE
DI NG
DI
SO RD
ER S
55 54
