FACTOR XIII (FXIII) (2)

Autosomal recessive inheritance. Umbilical cord bleeding is common in FXIII deficiency. Some patients sustain a spontaneous intracranial hemorrhage, a brain bleed, which is the leading

cause of mortality. Other symptoms of FXIII deficiency include bruising, nose and mouth bleeds, muscle bleeds and delayed bleeding after surgery.

Women can experience menorrhagia, long, heavy menstrual periods, and repeat miscarriages. Men with FXIII deficiency may show signs of infertility. Acquired FXIII deficiency can be observed in presence of autoantibodies.

BIOPHEN™ Factor XIII Determination of FXIII activity in human citrated plasma. Reagent and material required: automatic instrument for chromogenic assays with a wavelength

at 340 nm.

REAGENT Product Name RS Ref. Presentation

BIOPHEN™ Factor XIII CE-IVD 227005

R1: 3 x 4 mL

R2: 3 x 5 mL

Research

Factor XIII Deficient Plasma For any study or research protocol where a source of human FXIII deficient plasma is required.

REAGENT Product Name RS Ref. Presentation Factor XIII

Deficient Plasma

RUO DP200K 6 x 1 mL

Research

ZYMUTEST™ Factor XIII-A Measurement of FXIII (subunit A) in human plasma, by Elisa.

COMPLETE SOLUTION Product Name RS Ref. Presentation

ZYMUTEST™ Factor XIII-A RUO

RK034A on demand

96 tests

FACTOR II (FII) / PROTHROMBIN (1,2,3)

Autosomal recessive inheritance. Prothrombin deficiency is a rare hereditary coagulation disorder. Symptoms include excessive umbilical cord bleeding, easy bruising, frequent nosebleeds and

hemorrhaging after surgery or trauma. Women with FII deficiency experience menorrhagia, heavy menstrual bleeding, and postpartum hemorrhage after childbirth.

Dysprothrombinemia results from a protein abnormality, which affects prothrombin clotting activity. Hypoprothrombinemia occurs when prothrombin concentration is decreased.

Factor II Deficient Plasma Used in combination with PT-Phen™ (ref. CK581 - CK582 - CK583 - CK584K - CK584L - CK586K - CK586L) to measure Factor II (FII or Prothrombin) clotting activity in human citrated plasma.

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

Prothrombin Deficient Plasma

CE-IVD DP010A 1 x 1 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 DP010K 6 x 1 mL

FACTOR V (FV) (1)

Autosomal recessive inheritance. FV is deficient in presence of congenital or acquired FV deficiencies, hepatic disorders or

accelerated clotting factor consumption (DIC). High levels of FV are risk factors for venous thrombosis.

Factor V Deficient Plasma Used in combination with PT-Phen™ (ref. CK581 - CK582 - CK583 - CK584K - CK584L - CK586K - CK586L) to measure FV or Proaccelerin activity in human citrated plasma.

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

Factor V Deficient Plasma

CE-IVD DP020A 1 x 1 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 DP020K 6 x 1 mL

Research

ZYMUTEST™ Factor V Measurement of human FV antigen in plasma, by Elisa.

COMPLETE SOLUTION Product Name RS Ref. Presentation

ZYMUTEST™ Factor V RUO

RK009A on- demand

96 tests

(1) cf Dedicated intructions for use - (2) www.afh.asso.fr - (3) www.hemophilia.org (2) www.hemophilia.org

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