ANTITHROMBIN (AT) (1)

Spontaneous thromboembolic diseases are observed in presence of congenital or acquired deficiencies of antithrombin. These deficiencies are classified in 4 different groups: Type I: Decreased AT concentration and decreased AT activity; this is the most frequent case. Type II RS (Reactive Site): Normal AT concentration and decreased biological activity; a protein

abnormality is present at the active site. Type II HBS (Heparin Binding Site): Normal AT concentration, normal AT activity in the absence

of heparin, but decreased in its presence. Type II (Pleiotropic): Decreased AT concentration and activity; nonfunctional protein and at

a lowered level.

BIOPHEN™ AT anti - (h) - Xa LRT Determination of AT activity in human citrated plasma, using an anti-Xa chromogenic method (Human Xa).

REAGENT CALIBRATOR CONTROLS

Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

BIOPHEN™ AT anti-(h)- Xa LRT Liquid and Ready to use

CE-IVD 221123

R1: 3 x 3 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 R2: 3 x 3 mL

221127 R1: 4 x 7.5 mL R2: 4 x 7.5 mL

BIOPHEN™ AT LRT Determination of the heparin cofactor activity of AT in human citrated plasma, using an anti-Xa chromogenic method (Bovine Xa).

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

BIOPHEN™ AT LRT Liquid and Ready to use

CE-IVD 221111 R1: 4 x 11 mL BIOPHEN™

Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301 R2: 4 x 4 mL

BIOPHEN™ Antithrombin Determination of AT activity in human citrated plasma, using an anti-Xa chromogenic method (Human Xa).

REAGENT CALIBRATOR CONTROLS Product Name RS Ref. Presentation Product Name Ref. Product Name Ref.

BIOPHEN™ Antithrombin

CE-IVD 510(k)

221102 R1: 2 x 2.5 mL

BIOPHEN™ Plasma Calibrator

222101

BIOPHEN™ Normal Control Plasma

BIOPHEN™ Abnormal Control Plasma

223201

223301

R2: 2 x 2.5 mL R3: 2 x 5 mL

221105

R1: 4 x 5 mL R2: 4 x 5 mL

R3: 4 x 10 mL

(1) cf Dedicated intructions for use

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